4. MEDICATION ABORTION
Updated 2025 by Jackie Mostow, MD, Allison Slater, MD, MBE, and Ellen Stoke, MD
Medication abortion (MAB), most often through the use of mifepristone and misoprostol or misoprostol alone, provides a safe, effective method of pregnancy termination. MAB is increasingly used globally and in the United States (U.S.). It can be offered in diverse settings without special equipment. This process may allow for people to utilize abortion care where they live and may be accessible where procedural abortion care is not. It has long been utilized outside of the formal health care system for self-managed medication abortion (SMMA) (see Ch. 2: Self Managed Abortion).
Chapter Learning Objectives
At the end of this chapter you should be able to:
- Effectively counsel patients regarding MAB
- Evaluate patients for eligibility prior to MAB
- Discuss criteria for additional follow-up and manage as needed
- Provide MAB and telehealth MAB to appropriate patients
- Understand how misoprostol with or without mifepristone is used for self-managed medication abortion
Videos
- Medication Abortion in Primary Care (TEACH; with optional CME)
- Medication Abortion (IERH)
- Telemedicine for Medication Abortion (IERH)
Resources
- NAF Clinical Practice Guidelines—Early Medication Abortion (NAF 2024)
- WHO Abortion Care Guideline (WHO 2022)
- Medication Abortion Guidance (ACOG 2020, ACOG 2023)
- Medication Abortion Protocol (Access Bridge)
- Ipas Clinical Updates in Reproductive Health: Medication Abortion (Ipas 2023)
- Access Delivered MAB Provider Toolkit (UW): step-by-step guide to help integrate MAB services
- Mifepristone manufacturers (with on-call networks)
- Danco (https://www.earlyabortionpill.com)
- GenBioPro (https://genbiopro.com)
- Reproductive Health Hotline (ReproHH): For clinicians by clinicians. Free, confidential, evidence-based hotline for repro health providers (1-844-REPROHH (1-844-737-7644))
- Additional helpful resources for patients: See Ch. 9: Patient Support and Education