"

15 Is DNA Destiny?

(Another look at the Nature Nurture Debate)

Purpose: 

To examine and discuss currrent research on the complex physical, social and environmental factors that contribute to mental health.

Learning Objectives

Participants will:

  1. Examine current research on the aspects of physical and mental health that are determined by genetics,  environment and personal factors.
  2.  Begin the process of exploring locus of control and personal strategies that could be helpful to health and wellbeing.

Jig-Saw Learning Activity to explore current understandings of mental health

What is jigsaw Learning?

Jigsaw is a cooperative learning strategy that enables each student of a “home” group to specialize in one aspect of a topic (for example, one group studies habitats of rainforest animals, another group studies predators of rainforest animals). Students meet with members from other groups who are assigned the same aspect, and after mastering the material, return to the “home” group and teach the material to their group members. With this strategy, each student in the “home” group serves as a piece of the topic’s puzzle and when they work together as a whole, they create the complete jigsaw puzzle.

Purpose of Jig Saw Learning Activity

 

Activity Directions:

1. Prepare articles ahead of time: Have the following three articles ready as links or photo-copy each article for a third of the group.  Assign everyone in the large group to one of the three articles.  Give them 15 minutes to read their passage and write down 3-5 main ideas in point form.
2.  Triads:  Divide the class into groups of three with one person from each article represented in the triad.   Ask them to share their key take-aways from their articles and then as a group discuss:
  • How much of our overall health is determined and how much do we have control over?   
  • What things related to mental health are within your locus of control and which things are not?
  • Based on what we have read and discussed, what are your group’s top 5 recommendations to boost wellbeing?

3.   Full Group Closing Reflection: Facilitator can ask if anyone wants to share reflections from this session’s content.  A final wrap-up summary could include these points:

Key Takeaways

  • Health, mental health and wellbeing all influence each other and arise from complex genetic, family and social factors.
  • The new field of epigenetics is finding that people can have vulnerabilities or genetic pre-dispositions to some disorders or diseases, but these might only become “turned on” if there are significant triggers or stresses that impact psychological and/or physical health.
  • It can also be important use critical analysis to explore the power dynamics,  social messages,  and oppressive forces that often influence mental health and resilience. Multi-generational patterns of trauma, poverty, violence, colonialism, racism, sexism and other repressive forces need to be unravelled so that an individual can look clearly at the complex variables that influence their current state of well-being. It can be empowering for individuals to recognize the personal resources that they have developed to survive and stand up to the negative messages or circumstances that have influenced their personal circumstances and narratives.
  •   It is also true that we all have some control over making the best of the “cards we are dealt” to influence our overall health and happiness.
  • Dr. Emma McAdam states, “I really don’t believe that your genes or history are your destiny. Each of us has some influence over our own lives and happiness. And again, just focus on your locus of control. Change the things that you can change, and practice accepting the things that you can’t change. “

Three Articles for Jig-Saw Activity

# 1 Disease, Health and Genetics

In the largest meta-analysis ever conducted, scientists have examined two decades of data from studies that examine the relationships between common gene mutations, also known as single nucleotide polymorphisms (SNPs), and different diseases and conditions. And the results show that the links between most human diseases and genetics are shaky at best.

“Simply put, DNA is not your destiny, and SNPs are duds for disease prediction,” said David Wishart, professor in the University of Alberta’s Department of Biological Sciences and the Department of Computing Science and co-author on the study. “The vast majority of diseases, including many cancers, diabetes, and Alzheimer’s disease, have a genetic contribution of 5 to 10 per cent at best.”

The study also highlights some notable exceptions, including Crohn’s disease, celiac disease, and macular degeneration, which have a genetic contribution of approximately 40 to 50 per cent.

“Despite these rare exceptions, it is becoming increasingly clear that the risks for getting most diseases arise from your metabolism, your environment, your lifestyle, or your exposure to various kinds of nutrients, chemicals, bacteria, or viruses,” explained Wishart.

Wishart and his research collaborators suggest that measuring metabolites, chemicals, proteins, or the microbiome provides a much more accurate measure of human disease risk and are also more accurate for diagnosis. The findings fly in the face of many modern gene testing businesses models, which suggest that gene testing can accurately predict someone’s risk for disease.

“The bottom line is that if you want to have an accurate measure of your health, your propensity for disease or what you can do about it, it’s better to measure your metabolites, your microbes or your proteins — not your genes,” added Wishart. “This research also highlights the need to understand our environment and the safety or quality of our food, air, and water.”

sciencedaily.com/releases/2019/12/IS DNA destiny

#2 Mental Health, Genetics and Epigenetics

There are no mental health conditions that I know of that are 100% genetic. There is no single gene for any condition that we know of. There is not a depression gene or a bipolar gene.

Mental health conditions are caused by a whole bunch of complicated interplays between a bunch of different genes and our environment and how we think.

So the old debate, “Is it nature or nurture?” has given way to a much more nuanced exploration of how nurture — the experiences we have — turn on or turn off various genes, nature. This is called epigenetics.

So research shows that someone who experiences trauma, for example, is much more likely to develop depression or diabetes because some genes get turned on by those experiences, and even more, those genes that get turned on are more likely to get passed on.

So our experiences interplay with our biology in a way that scientists are just beginning to explore. And this is called epigenetics. It shows that with any set of genes we all have a spectrum, a degree of influence within our biological inheritance.

So in my opinion, life is about what we will do with what we have, how we’ll play the cards we were given, and I believe there’s a lot of room for growth and change.

Heritability Estimates

Now, that being said, biological influences do exist, and researchers have been able to study this in two ways: by comparing twins and by researching people that were adopted and raised in a completely different environment than their biological parents.

So really smart statisticians and researchers have looked at lots of data and estimated how much genetics contribute to mental illness. So that being said, let’s look at the numbers.

These are the heritability estimates: researchers believe that depression is 30 to 42% heritable, general anxiety disorder around 31%, panic disorder around 43%, schizophrenia between 73 and 90%, bipolar disorder between 60 and 85%, OCD around 47%, ADHD between 60 and 80%.

Pervasive developmental disorders like autism are around 90% heritable. They’re highly neurodevelopmental. But there is a spectrum of functioning with all disorders.

Anorexia they estimate between 48 and 88%, and with bulimia 28 to 83%.

So you can see with these later ones there’s a lot bigger margin of error. They’re not really sure how genes play into those.

So autism, schizophrenia, bipolar, and ADHD are some of the most heritable disorders, whereas depression and anxiety disorders seem to be influenced more by environmental and psychological factors.

This does not mean that 42% of your depression is caused by genes and 58% is caused by other factors. It’s way more complex than that. According to the American Journal of Psychiatry, heritability does not really tell you how genetic a disease is but rather how important genes are compared with other risk factors in a given population at a given time.

So for example, your height is like 90% genetic, but nutrition, injuries, illnesses, cancer on the pituitary gland, etc., these can all impact how tall you grow. And within a single disorder like depression, for example, some forms seem to be more heritable. So if you develop depression at an early age, if it’s recurrent, if it’s more severe, or if you also have an anxiety disorder, your depression is more likely to be genetically influenced.

So what do we do with this information? Can genetic testing tell you if you have a higher risk? The answer is no, not yet. The genetic influences are just too complicated for our level of science at this point. But maybe one day in the future we will be able to better understand our risks through genetic tests. You can look at your family tree to be more informed.

But just because another family member has a condition doesn’t mean you will too. So if you have a sibling with depression, your risk of also having it is two to three times greater. If one parent has schizophrenia, your chances of getting it is 10%, but if both parents have schizophrenia then you have a 40% chance of developing the disorder.

It’s also important to know that predispositions may lower the threshold. They make it so that a certain trigger is more likely to cause bipolar in an individual with that predisposition than in someone else without that predisposition. Genes can turn on traits during the lifespan.

how-genetic-is-mental-illness.

 

#3 Are Wellbeing and Happiness Genetic? 

Some people seem to be born with a happier, carefree disposition than others, and research indicates that — yes — some of your sense of well-being may be in your genes. But only partly.

Your genes make up an estimated 40% of your ability to be happy, says psychotherapist Susan Zinn of Susan Zinn Therapy.

But that doesn’t mean that if you weren’t born with certain genes, you’re destined to be unhappy.

Zinn says that “it’s completely possible to rewire our brains for happiness,” because the other 60% of happiness comes down to lifestyle and other environmental factors.

Learn more about how your genetic makeup contributes to your life satisfaction and how you can increase feelings of happiness and well-being regardless of your genetic sequence.

What is happiness?

Happiness is typically determined by three main components, according to Zinn:

  • Life satisfaction. This is usually linked to positive emotions based on past, present, and projected future experiences. Specifically, your past can influence future life satisfaction by how you frame the future in your mind. For instance, if you suffered from trauma in the past, then you may think your future will not be satisfying because you envision worst-case scenarios.
  • Feeling engaged with what you do every day. Be it at work, in relationships, or in your leisure time, it’s important to feel invested in the people you spend time with, your career, or hobbies. According to a 2021 study, having more optimism and happiness can boost your performance at work.
  • Having meaning and purpose in life. This may be described as feeling that what you do in life is important, that you have goals or aspirations, or perhaps what you do helps others.

Research indicates that we can inherit many traits including optimism, self-esteem, and happiness. So by that logic, yes, there are genes that may predispose you to a happier disposition.

For example, a 2011 study found promising evidence that people with a certain form of the gene called 5-HTTLPR reported higher life satisfaction.

And a landmark 2016 study that formally linked happiness to genetics involved the DNA of nearly 300,000 people. The researchers pinpointed three specific genetic variants associated with well-being. But they also found that these genetic variations weren’t the only factor. An interplay of genetics and environment also contributed to happiness.

How to be happy 

“You have a choice,” Zinn says. “It’s no different than deciding what to wear or what food to order. When it comes to happiness, there’s a lot we can do about it.”

Despite your genetic makeup, there are ways you can learn to be happier, even in difficult times. Other traits, such as resilience, can be cultivated over time.

Here are eight practical ways to choose happiness:

  1. Let go of perfectionism. One way to achieve a happier state is to let go of a quest for perfectionism that focuses only on the end goal of success, Zinn says. Linking happiness with perfectionism and success is common in American culture, but it leads you to concentrate on the summit of what you want to achieve rather than the journey of what happens along the way.
  2. Volunteer. Doing something for others takes the focus off of yourself and can make you feel good, according to 2020 research. Even if you can’t make a regular commitment to volunteer, think of small things you can do to help others, such as picking up groceries for someone not able to get them on their own.
  3. Exercise. Physical activity isn’t just helpful for your body — it’s also great for your mind, Zinn says. Movement helps to release the feel-good chemical dopamine. Current federal guidelines recommend 150 minutes of moderate physical activity a week, which breaks down to 30 minutes, five days a week.
  4. Nutrition. A healthy diet can have a huge effect on your self-confidence, health, and subsequent happiness. If you’re wondering what type of foods to eat, a 2012 study found a plant-based diet can improve your mood. Moreover, the DASH diet and Mediterranean diet come highly recommended by nutritionists.
  5. Get out in nature. Nature helps you to feel humbled by what’s around you, reduces stress, and helps you feel more connected to the world, which can lead to higher life satisfaction, Zinn says.
  6. Show gratitude and practice kindness. One way to do this, according to Zinn: Keep a kindness jar with a notepad and pen nearby. Everyone at home can write down kind acts they have done in a given week or that others have done for them. At the end of the week, you can choose what to do with the items in the jar, such as reading them aloud.
  7. Laugh. People who can find humor in even the darkest or craziest of circumstances are often able to boost their happiness.
  8. Tune in to meaning and spirituality. Mindfulness meditationreligion, believing in a higher power, or a connection to a higher consciousness may help give a greater feeling of purpose in life.   https://www.insider.com/guides/health/mental-health/is-happiness-genetic

 

Extention Activity:  Watch  Dr. Emma McAdam’s video that provides current research on mental illness, heredity and personal agency around well-being and facilitate discussion about her main points.

RESOURCES NEEDED:

  • Copies of the three articles about health and destiny. You will need enough copies of each article for one third of the group.  Or you could send links of each article to a third of the group.
  • Participants will need a learning journal, notebook or tablet to write notes for their asessment and reflections.

License

Icon for the Public Domain license

This work (Pathways to Connection: by Robin Higgins) is free of known copyright restrictions.