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“Genetics” is the study of how traits are inherited.A trait is defined as a variation in the physical appearance of a heritable characteristic. It seeks to understand how traits are passed from generation to generation. Before you start learning about the details of inheritance, let’s review some topics that are important in order to understand genetics.

Recall that genes are segments of DNA that are typically several hundred or thousand bases long. Each gene directs the production of a protein through the process of protein synthesis: DNA gets transcribed to produce an mRNA; mRNA provides to code for a ribosome to produce a chain of amino acids. Read this section of the book if you need to review this topic: How do genes direct the production of proteins?

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The Central Dogma – DNA is used to make RNA is used to make protein

Recall that genes are found on chromosomes and that each chromosome typically contains hundreds or thousands of genes. In humans and other animals, each cell contains two copies of each chromosome. The reason we have two copies of each gene is that we inherit one from each parent. In fact, it is the chromosomes we inherit and the two copies of each gene are located on paired chromosomes.Read this section of the book if you need to review this topic: How DNA is arranged in the cell

Figure 3: There are 23 pairs of chromosomes in a female human body cell. These chromosomes are viewed within the nucleus (top), removed from a cell during cell division (right), and arranged according to length (left) in an arrangement called a karyotype. In this image, the chromosomes were exposed to fluorescent stains to distinguish them. (credit: “718 Bot”/Wikimedia Commons, National Human Genome Research)
There are 23 pairs of chromosomes in a female human body cell. These chromosomes are viewed within the nucleus (top), removed from a cell during cell division (right), and arranged according to length (left) in an arrangement called a karyotype. In this image, the chromosomes were exposed to fluorescent stains to distinguish them. (credit: “718 Bot”/Wikimedia Commons, National Human Genome Research)

Chromosomes are inherited by the offspring from the parents via the egg or sperm. Inside one egg or one sperm is one copy of each chronometer (so 23 total in humans). When an egg is fertilized by a sperm, the resulting zygote (fertilized egg) will contain two copies of each chromosome, just like each of its parents.

Meiosis is the process that produces eggs and sperm. Eggs and sperm are also known as gametes. During meiosis, one copy of each paired chromosome is moved into the gamete. Cells with one copy of each chromosome are known as “haploid“. This separation, or segregation, of the homologous (paired) chromosomes means also that only one of the copies of the gene gets moved into a gamete.

The offspring are formed when that gamete unites with one from another parent and the two copies of each gene (and chromosome) are restored. Read this section of the book if you need more information on this topic: Overview of Meiosis

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During meiosis, the DNA is copied once, then the cell divides twice. This produces cells with half as much genetic information as the original cell (1 copy of each chromosome). These cells become the sex cells (eggs or sperm). When two sex cells unite during fertilization, the original number of chromosomes (2 copies of each one) is restored.

The offspring will receive two copies of each gene (one from each parent), but the copies are not necessarily identical. You already knew this – you don’t get identical information from your mother and your father because they have different DNA (which gives them different traits). The different versions of one specific gene are known as alleles. As you learn about genetics, you will learn about how the information from both alleles of a specific gene interact to give an individual their trait. The genetic information that an individual has is called their genotype. The genotype of an individual produces the individual’s phenotype, or physical traits.

References

Unless otherwise noted, images on this page are licensed under CC-BY 4.0 by OpenStax.

OpenStax, Concepts of Biology. OpenStax CNX. May 18, 2016 http://cnx.org/contents/s8Hh0oOc@9.10:8v2Xzdco@5/The-Structure-of-DNA

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MHCC Biology 112: Biology for Health Professions Copyright © 2019 by Lisa Bartee is licensed under a Creative Commons Attribution 4.0 International License, except where otherwise noted.

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